Measurements of upper and lower airway nitric oxide in healthy adults
Introduction. Nasal nitric oxide (NO) measurement can be a useful tool for monitoring upper airway
diseases. However, there is a considerable lack of validation data. Aims. To evaluate the
repeatability and intra-subject variations of nasal NO output ( nV NO ) in healthy adults and to
study its correlation with lower airway NO parameters. Methods. nV NO was measured in healthy
non-smokers at baseline ( N = 31, age: 28 ± 6 years), after 1 h ( N = 15), 1 d ( N = 15), 1 week ( N
= 17), and compared using the Bland –Altman method. At baseline, lower airway NO parameters ( F ENO ,
flux of NO in the conducting airways and alveolar NO concentration) were also measured and
correlated to nV NO (Spearman correlation). Multivariate regression analysis was used to assess the
factors influencing nV NO . Results. Baseline median nV NO was 4...
Source: Journal of Breath Research - Category: Respiratory Medicine Authors: Bal ázs Csoma, Filippa Beringer, Gergő Szűcs, András Bikov, Veronika Müller and Zsófia Lázár Source Type: research