Nintedanib ameliorates imiquimod-induced psoriasis in mice by inhibiting NF- κB and VEGFR2 signaling

In this study, we explored the potential effects and mechanisms of nintedanib on psoriasis in vivo and in vitro. In vivo experiments showed that nintedanib effectively alleviated imiquimod-induced psoriasis-like skin lesions and reduced psoriasis severity index scores. For the mechanism research, we mainly focused on the abnormal phenotype of keratinocyte in the pathogenesis of psoriasis. We used HaCaT cells in the in vitro experiments and the result revealed that nintedanib restored keratinocyte homeostasis by downregulated the expression of proinflammatory factors, inhibited hyperproliferation, promoted apoptosis, maintained normal differentiation via regulating the NF-κB pathway. In addition, nintedanib regulated angiogenesis by inhibiting VEGFR2 activity. In summary, our study indicated that nintedanib is a promising candidate medication for psoriatic treatment.PMID:34547680 | DOI:10.1016/j.intimp.2021.108129

Source: International Immunopharmacology - September 21, 2021 Category: Allergy & Immunology Authors: Xiaohe Li Buri Xi Yang Miao Xiaoyang Ma Jianwei Zhang Jingjing Gao Wenguo Wei Honggang Zhou Cheng Yang Source Type: research