Geranylgeranyl diphosphate synthase 1 knockdown suppresses NLRP3 inflammasome activity via promoting autophagy in sepsis-induced acute lung injury

CONCLUSION: GGPPS1 knockdown suppressed NLRP3 inflammasome activity via promoting autophagy and then attenuated sepsis-induced acute lung injury, revealing a novel target for treating sepsis-induced lung injury.PMID:34530204 | DOI:10.1016/j.intimp.2021.108106

Source: International Immunopharmacology - September 16, 2021 Category: Allergy & Immunology Authors: Dahuan Li Chunyan Li Tianzhong Wang Chong Zhang Zhao Zhu Guoxiu Zhang Bangjiang Fang Source Type: research