Quantitative 3D microscopy highlights altered von Willebrand factor α-granule storage in patients with von Willebrand disease with distinct pathogenic mechanisms

CONCLUSIONS: Our findings highlight the utility of quantitative imaging approaches in assessing platelet granule content, which may help to better understand VWF storage in α-granules and to gain new insights in the etiology of VWD.PMID:34532631 | PMC:PMC8440947 | DOI:10.1002/rth2.12595

Source: Thrombosis and Haemostasis - September 17, 2021 Category: Hematology Authors: Maurice Swinkels Ferdows Atiq Petra E B ürgisser Johan A Slotman Adriaan B Houtsmuller Cilia de Heus Judith Klumperman Frank W G Leebeek Jan Voorberg Arend Jan Gerard Jansen Ruben Bierings Source Type: research