The impact of CD4+CD28null T lymphocytes on atrial fibrillation: a potential pathophysiological pathway

ConclusionConsidering the available data in the literature, it needs to be assumed that CD4+CD28null T lymphocytes are mainly involved in the development of AF and disease progression. Of utmost importance, it can be considered as the result of a T-cell-mediated auto-immune reaction among myocardial tissue. However, mechanisms which recruit CD4+CD28null cells in cardiac tissue remain unclear and need further investigation.
Source: Inflammation Research - Category: Research Source Type: research

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Mol Med Rep. 2021 Dec;24(6):870. doi: 10.3892/mmr.2021.12510. Epub 2021 Oct 26.ABSTRACTAtrial fibrillation (AF) is one of the most common forms of cardiac arrhythmia. Novel evidence has indicated that a competing endogenous RNA (ceRNA) mechanism may occur in AF. The present study aimed to identify differentially expressed microRNAs (miRNAs/miRs) in AF and predict their targeting long non‑coding RNAs (lncRNAs) to identify a potential ceRNA network involved in AF using bioinformatics analysis. The GSE68475 microarray dataset was downloaded from the Gene Expression Omnibus database and differentially expressed miRNAs in AF ...
Source: Molecular Medicine Reports - Category: Molecular Biology Authors: Source Type: research
Hamostaseologie. 2021 Oct;41(5):372-378. doi: 10.1055/a-1581-6881. Epub 2021 Oct 25.ABSTRACTSince the coronavirus disease (COVID-19) pandemic spread unrelentingly all over the world, millions of cases have been reported. Despite a high number of asymptomatic cases, the course of the disease can be serious or even fatal. The affection of the myocardium, called myocardial injury, is caused by multiple triggers. The occurrence of cardiac arrhythmias in COVID-19 patients with myocardial involvement and a critical course is common. In this review, potential mechanisms, incidence, and treatment options for cardiac arrhythmias in...
Source: Hamostaseologie - Category: Hematology Authors: Source Type: research
Orv Hetil. 2021 Oct 10;162(41):1643-1651. doi: 10.1556/650.2021.32194.ABSTRACTÖsszefoglaló. A ritmuszavarok előfordulása gyakoribb a terhes nők esetén, mint a nem várandósok körében. A legtöbb esetben terápiás beavatkozás nélkül is kihordható a magzat. Hemodinamikai instabilitás és magzatkárosodáshoz vezető fetalis hypoperfusio jöhet létre, amennyiben tartós, magas kamrai frekvenciával járó epizódok jelentkeznek. Ezekben az esetekben a ritmuszavar meg...
Source: Orvosi Hetilap - Category: General Medicine Authors: Source Type: research
This study adopts a randomized double-blind, single-simulated, placebo-controlled research method. Participants were randomly assigned in a 1:1 ratio through a centrally controlled, computer-generated, simple randomization schedule. Participants would take the medicine for 1 month, and the curative effect would be evaluated. Subsequently, the participants would not take TCM and only receive western medicine treatment. They would be followed up for another 8 weeks, and a clinical evaluation would be conducted. The secondary outcomes include echocardiography, Hamilton Anxiety Scale, Hamilton Depression Scale, rate of increas...
Source: Trials - Category: Research Source Type: clinical trials
by Rupamanjari Majumder, Sayedeh Hussaini, Vladimir S. Zykov, Stefan Luther, Eberhard Bodenschatz Interruptions in nonlinear wave propagation, commonly referred to as wave breaks, are typical of many complex excitable systems. In the heart they lead to lethal rhythm disorders, the so-called arrhythmias, which are one of the main causes of sudden death in the industrialized world. Progress in t he treatment and therapy of cardiac arrhythmias requires a detailed understanding of the triggers and dynamics of these wave breaks. In particular, two very important questions are: 1) What determines the potential of a wave break t...
Source: PLoS Computational Biology - Category: Biology Authors: Source Type: research
ConclusionNOAF is a common occurrence in critically ill patients with sepsis, and its incidence rises with increasing severity of disease. Our Meta-analysis suggests that it is independently associated with poor outcome. In view of these findings there is a need for better quality observational studies, because reliable identification of patients with sepsis who are prone for the development of AF may allow for early pharmacological interventions to prevent this complication.
Source: QJM - Category: Internal Medicine Source Type: research
Over 37 million people suffer from atrial fibrillation (AF), the most common sustained cardiac arrhythmia[1]. The number of patients hospitalized by AF is increasing 8% annually[2], largely due to the rising prevalence of AF[3] and the invasiveness and/or limitations of current treatment options. Cardiac radioablation (CR) may offer a non-invasive, quick, and cost-effective treatment alternative to help relieve this socio-economic and health burden.
Source: Radiotherapy and Oncology - Category: Radiology Authors: Tags: Original Article Source Type: research
Atrial fibrillation (AF) is the most common cardiac arrhythmia worldwide with an increasing risk of heart failure, stroke, and thromboembolic events. Currently distinct pathophysiological mechanisms during AF development and valuable biomarkers for AF management remain unknown.
Source: International Journal of Cardiology - Category: Cardiology Authors: Source Type: research
ConclusionWe found no associations between markers of immunothrombosis and new-onset AF in the general population. Inflammation and immunothrombosis may be associated with AF through other cardiovascular risk factors or predisposing conditions of AF. Our findings challenge the added value of biomarkers in AF risk prediction.Graphic abstract
Source: Clinical Research in Cardiology - Category: Cardiology Source Type: research
In this study, we aimed to investigate the relationship between EFT thickness and the development of new-onset AF in patients with NSTEMI during in-hospital follow-up.METHODS: We enrolled 493 consecutive patients who were diagnosed NSTEMI in this study. During in-hospital follow-up, 68 patients developed AF, and the remaining 425 patients were determined as the control group. The thrombolysis in myocardial infarction (TIMI) risk score for NSTEMI was calculated. All clinical, echocardiographic, and laboratory parameters were compared between the 2 groups.RESULTS: EFT thickness was higher in the AF group than in the controls (p
Source: Turk Kardiyoloji Dernegi arsivi - Category: Cardiology Authors: Source Type: research
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