From the Editor ’s Desk…

Many recent observations emphasise that hepatocellular carcinoma (HCC) developing on the background of non-alcoholic steatohepatitis (NASH) has distinct features, e.g. less efficacious responses to immunotherapy, but the molecular characteristics of NASH-HCC are not well defined. Pinyol and coworkers analysed transcriptomic and whole exome sequencing data from a large number of NASH, NASH-HCC and non-NASH-HCC samples, alongside analyses of 3 commonly used mouse models of NASH-HCC. Human NASH-HCC has higher rates of (potentially tumour-suppressing) ACVR2A mutations (10%), some typical mutational patterns, a Wnt/TGF- β proliferation subclass (42%) and immunosuppressive traits in the adjacent non-tumoral tissue.

Source: Journal of Hepatology - September 15, 2021 Category: Gastroenterology Authors: Patrizia Burra, Frank Tacke, Vlad Ratziu, Stefan Zeuzem, Bruno Sangro, Paolo Angeli Tags: From the Editor's Desk Source Type: research