A novel mechanism of Imeglimin ‐mediated insulin secretion via the cADPR ‐ TRP channel pathway

ConclusionsImeglimin may activate TRPM2 channels in β-cells via the production of NAD+/cADPR, leading to the potentiation of GSIS. Developing approaches to stimulate cADPR-TRPM2 signaling provides a potential therapeutic tool to treat type 2 diabetes.

Source: Journal of Diabetes Investigation - September 15, 2021 Category: Endocrinology Authors: Shunsuke Funazaki, Masashi Yoshida, Hodaka Yamada, Masafumi Kakei, Masanobu Kawakami, Shuichi Nagashima, Kazuo Hara, Katsuya Dezaki Tags: ORIGINAL ARTICLE Source Type: research