Analysis of contamination in cluster randomized trials of malaria interventions

ConclusionsA sigmoid approach provides an appropriate analysis for a CRT in the presence of contamination. Outcome data from boundary zones should not be discarded but used to provide estimates of the contamination range. This gives an alternative to “fried egg” designs, which use large clusters (increasing costs) and exclude buffer zones to avoid bias.
Source: Trials - Category: Research Source Type: clinical trials