Ryanodine receptor as insecticide target

Curr Pharm Des. 2021 Sep 2. doi: 10.2174/1381612827666210902150224. Online ahead of print.ABSTRACTRyanodine receptor (RyR) is one of the primary targets of commercial insecticides. The diamide insecticide family, including flubendiamide, chlorantraniliprole, cyantraniliprole, etc, targets insect RyRs and can be used to control a wide range of destructive agricultural pests. The diamide insecticides are highly selective against lepidopteran and coleopteran pests with relatively low toxicity for non-target species, such as mammals, fishes, and beneficial insects. However, recently mutations identified on insect RyRs have emerged and caused resistance in several major agricultural pests throughout different continents. This review paper summarizes the recent findings on structure and function of insect RyRs as insecticide target. Specifically, we examine the structures of RyRs from target and non-target species, which reveals the molecular basis for insecticide action and selectivity. We also examine the structural and functional changes of RyR caused by the resistance mutations. Finally, we examine the progress in RyR structure-based insecticide design, and discuss how this might help the development of new generation of green insecticides.PMID:34477510 | DOI:10.2174/1381612827666210902150224
Source: Current Pharmaceutical Design - Category: Drugs & Pharmacology Authors: Source Type: research