Resident human dermal γδT-cells operate as stress-sentinels: Lessons from the hair follicle

In conclusion, human dermal γδT-cells exert physiological stress-sentinel functions in human skin, where their excessive activity can promote autoimmunity towards stressed HFs that overexpress CD1d, CXCL12, and/or MICA.PMID:34479087 | DOI:10.1016/j.jaut.2021.102711

Source: Journal of Autoimmunity - September 3, 2021 Category: Allergy & Immunology Authors: Youhei Uchida Jennifer Gherardini Karin Pappelbaum J érémy Chéret Andreas Schulte-Mecklenbeck Catharina C Gross Natasa Strbo Amos Gilhar Alfredo Rossi Wolfgang Funk Takuro Kanekura Lu ís Almeida Marta Bertolini Ralf Paus Source Type: research