Multi-omics study on biomarker and pathway discovery of chronic obstructive pulmonary disease

Chronic obstructive pulmonary disease (COPD) is a common heterogeneous respiratory disease
characterized by persistent and incompletely reversible airflow limitation. Due to the heterogeneity
and phenotype complexity of COPD, traditional diagnostic methods can only provide limited
information on predicted results and treatment, which are not sufficient for accurate diagnosis and
evaluation. With the development of omics technologies in recent years, genomics, proteomics and
metabolomics are widely used in the study of COPD, providing good tools for discovering biomarkers
to diagnose and elucidate the complex mechanism of COPD. In this review, we summarize the biomarkers
of COPD based on metabolomic, proteomic and transcriptomic studies that have been reported in recent
years. Furthermore, protein –protein interactions and multi-omics integrated analyses were carried
out to explore the important metabolites and proteins that are involved in significant pathways in
the progression ...

Source: Journal of Breath Research - August 31, 2021 Category: Respiratory Medicine Authors: Yuqing Tang, Zhengjun Chen, Zhiling Fang, Jinshun Zhao, Yuping Zhou and Chunlan Tang Source Type: research