Quantitative Bioluminescence Tomography-guided Conformal Irradiation for Pre-clinical Radiation Research

Widely-used CBCT-guided irradiators in pre-clinical radiation research are limited to localize soft tissue target due to low imaging contrast. Knowledge of target volume is a fundamental need for radiotherapy (RT). Without such information to guide radiation, normal tissue can be over-irradiated, introducing experimental uncertainties. It led us to develop high contrast quantitative bioluminescence tomography (QBLT) for guidance. The use of 3D bioluminescence signal, related to cell viability, for pre-clinical radiation research is one step toward biology-guided RT.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Physics Contribution Source Type: research