P –295 Does endometriosis affect oocyte quality? An analysis of 13 627 donor oocyte recipient and autologous IVF cycles

AbstractStudy questionDoes endometriosis affect live birth following donor oocyte recipient versus autologous in vitro fertilisation (IVF) cycle.Summary answerThere was no significant difference in the live birth rate (LBR) in women with endometriosis undergoing donor oocyte recipient versus autologous IVF cycle.What is known alreadyFor infertile women with endometriosis, IVF is often considered as a treatment option. Lower implantation and pregnancy rates have been observed following IVF in women with endometriosis when compared to tubal factor infertility. It has been debated that lower pregnancy rates following IVF in endometriosis is due to both oocyte quality and the endometrium. To delineate whether endometriosis affects oocyte quality or the endometrium, we planned a study using donor oocyte recipient model where the recipient were women with endometriosis. We compared the LBR after oocyte recipient cycle with autologous IVF in women with endometriosisStudy design, size, durationWe obtained anonymised dataset of all the IVF cycles performed in the UK since 19991 from the Human Fertilization and Embryology Authority (HFEA). Data from 1996 to 2016 comprising a total of 13 627 donor oocyte recipient and autologous IVF cycles with endometriosis and no other cause of infertility were analysed.Participants/materials, setting, methodsData on all women with endometriosis undergoing fresh or frozen IVF treatment cycles were analysed to compare the LBR between donor oocyte recip...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research

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CONCLUSIONS: SIRT1 expression and progesterone resistance appears to play -roles in normal endometrial functions. Aberrant SIRT1 expression contributes to progesterone resistance and may participate in the pathophysiology of endometriosis. SIRT1 is a novel and targetable protein for the diagnosis as well as treatment of endometriosis and the associated infertility seen in this disease.PMID:34665857 | DOI:10.1210/clinem/dgab753
Source: The Journal of Clinical Endocrinology and Metabolism - Category: Endocrinology Authors: Source Type: research
To evaluate the effect of suppressive therapy on fertility and recurrence when administered after a conservative surgical treatment in women with endometriosis seeking pregnancy and to compare it with an inactive control.
Source: The Journal of Minimally Invasive Gynecology - Category: OBGYN Authors: Tags: 6055 Source Type: research
AbstractPurposeTo evaluate whether laparoscopic treatment with a diode laser is feasible, safe, and effective in symptomatic patients affected by deep endometriosis (DE).MethodsThis retrospective study was performed using medical record data. The surgical reports, chronic pain scores, and quality of life (QoL) data were evaluated for 50 patients who had undergone laparoscopic surgery between November 2017 and March 2019 at two university hospitals (Monserrato (CA) and Foggia, Italy). Indications for surgery were chronic pelvic pain and/or infertility in patients who wished to conceive spontaneously. Endometriosis lesions/n...
Source: Archives of Gynecology and Obstetrics - Category: OBGYN Source Type: research
J Obstet Gynaecol. 2021 Sep 29:1-7. doi: 10.1080/01443615.2021.1959536. Online ahead of print.ABSTRACTWe performed a retrospective cohort study, namely "Surgery and ART for Endometriomas" (SAFE) trial (Clinical Trial ID: NCT03717870), including women who underwent laparoscopic cystectomy for endometrioma before first IVF and compared their reproductive outcomes with the ones of women without endometriosis and with unexplained infertility, tubal factor or male factor infertility. We found that women who underwent previous laparoscopic cystectomy for endometrioma had higher FSH and LH levels between the 2nd and 5th...
Source: Journal of Obstetrics and Gynaecology - Category: OBGYN Authors: Source Type: research
Journal of Gynecologic Surgery, Ahead of Print.
Source: Journal of Gynecologic Surgery - Category: OBGYN Authors: Source Type: research
In conclusion, our results demonstrated that increased CD8+ T cells and CD56+ NK cells and decreased CD163+ macrophages within the eutopic endometria of women with endometriosis reveal a proinflammatory feature in the endometrial immune environment and that elevated CD8+ T cells increase the risk of infertility in women with the disease.
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Endometriosis is the most common gynecologic disease among infertile women. Its wide variability of symptoms usually makes diagnosis possible when already producing pelvic pain or infertility. Endometriosis medical management depends on the severity of the disease and several staging systems have been developed by scientific societies, trying to standardize the optimal strategy. Differences in reproductive outcomes have been found between women with mild and severe endometriosis. In cases of advanced disease, anatomical changes of the reproductive tract and smaller ovarian reserve are obvious limiting factors to get pregnant.
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Source Type: research
CONCLUSIONS: No studies reported on our primary outcome of live birth rate. Due to the very limited evidence, we are uncertain of the effects of pentoxifylline on clinical pregnancy rate, miscarriage rate, or overall pain. There is currently insufficient evidence to support the use of pentoxifylline in the management of women with endometriosis with respect to subfertility and pain relief outcomes.PMID:34431079 | DOI:10.1002/14651858.CD007677.pub4
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Source Type: research
AbstractSTUDY QUESTIONDoes ultra-long downregulation with a GnRH agonist (triptorelin depot) in previously operated patients with endometriosis improve the rate of clinical pregnancy with positive fetal heart beat (CPHB) in the subsequent initiated fresh ART cycle?SUMMARY ANSWERUltra-long downregulation with a GnRH agonist prior to ART did not improve the rate of CPHB in the subsequent fresh ART cycle in previously completely operated patients but the trial was underpowered due to early termination.WHAT IS KNOWN ALREADYAdministration of GnRH agonists for a period of 3 –6 months prior to ART in women with endometriosi...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research
AbstractStudy questionWhat is the prevalence of female infertility among UK military personnel and does it differ from the Metropolitan Police Service (MPS) and civilian populations?Summary answerPrevalence of self-reported infertility was higher in servicewomen (31.7%) and female MPS officers (36.3%) than in civilian women (24.4%).What is known alreadyArduous employment is associated with numerous potential occupational hazards and behaviours that may be relevant to fertility. These include physical and psychological stress, smoking, alcohol drinking and other lifestyle factors. A preliminarily report in 2016 indicated th...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research
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