AOP and IATA applied to ocular surface toxicity

Regul Toxicol Pharmacol. 2021 Aug 1;125:105021. doi: 10.1016/j.yrtph.2021.105021. Online ahead of print.ABSTRACTUntil now, the Draize test on rabbits has been the only test performed to anticipate ocular toxicity of pharmaceutical compounds, mainly irritation. The OECD is urging the scientific community to develop and validate alternative methods to reduce the need for animal testing. Since the models and tests used cannot reflect the entire biologic response, it is necessary to combine them into integrated approaches to testing and assessment (IATA) to obtain robust data. IATAs, along with adverse outcome pathways (AOP) that encompass molecular cascades and key events, require the best combinations of tests. This commentary manuscript describes these OECD tools and proposes original approaches for ocular surface AOP and an IATA for toxicity-induced dry eye (TIDE).PMID:34348128 | DOI:10.1016/j.yrtph.2021.105021

Source: Regulatory Toxicology and Pharmacology : RTP - August 4, 2021 Category: Toxicology Authors: No émie Bonneau Christophe Baudouin Fran çoise Brignole-Baudouin Source Type: research