Biomechanical changes in the lumbar spine following spaceflight 1 and factors associated with post2 spaceflight disc herniation

Background Context: For chronic low back pain, the causal mechanisms between pathological features from imaging and patient symptoms are unclear. For instance, disc herniations can often be present without symptoms. There remains a need for improved knowledge of the pathophysiological mechanisms that explore spinal tissue damage and clinical manifestations of pain and disability. Spaceflight and astronaut health provides a rare opportunity to study potential low back pain mechanisms longitudinally.
Source: The Spine Journal - Category: Orthopaedics Authors: Source Type: research

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CONCLUSION: Hypersensitive sinuvertebral and basivertebral nerves are strongly associated with epidural neovascularization with adhesion and the pathological pain pathway in degenerative disc disease. Epidural neovascularization with adhesion reflects aberrant neurological connections, which are associated with reflex inhibitory mechanisms of the multifidus muscle, which induces spasm. RFA treatment of the region of epidural neovascularization with adhesion effectively treated chronic discogenic back pain and could induce paraspinal muscle spasm release.PMID:34554709
Source: Pain Physician - Category: Anesthesiology Authors: Source Type: research
The majority of our knowledge of chronic pain in the general population comes from self-report studies. During the last three decades most of these population-based surveys have found that 20% to 35% of the general population suffer from chronic pain [4,6,10,22,23,25,27]. Globally, it is estimated that low back pain, migraine, neck pain, other musculoskeletal disorders, osteoarthritis, and tension type headache are rank numbered 1, 2, 6, 7, 12, and 28 with respect to causes of years lived with disability and that respectively 650, 850, 350, 250, 240, and 1560 million people worldwide suffer from these pain-related disorders [28].
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research
BMI (body mass index), CLBP (chronic low back pain), CPR (clinical prediction rule), F8WT (Figure-of-Eight Walk Test), LBP (low back pain), NMES (neuromuscular electrical stimulation), PT (physical therapist), QBPDS (Quebec Back Pain Disability Scale), RCR (Repeated Chair Rise Test), SSGS (self-selected gait speed), 6MWT (Six Minute Walk Test), SC (Stair Climbing Test), SEM (Structural Equation Modeling), TUG (Timed Up-and-Go Test)
Source: Archives of Physical Medicine and Rehabilitation - Category: Rehabilitation Authors: Tags: Original Research Source Type: research
This article reviews the history and current trends in use for lumbar toral disc arthroplasty for degenerative disc disease treatment. Furthermore, indications, contraindications, and complications management are discussed.
Source: Neurosurgery Clinics of North America - Category: Neurosurgery Authors: Source Type: research
Study Design. Retrospective. Objective. The aim of this study was to investigate the effect of body mass index (BMI) on pain and disability in patients with chronic mechanical low back pain (LBP) treated with multimodal rehabilitation. Summary of Background Data. Despite being a well-known risk factor for developing LBP, there is minimal data on the effect of BMI on pain and disability in patients with chronic mechanical low back pain (LBP) treated with multimodal rehabilitation. Methods. Data from patients with chronic mechanical LBP who underwent multimodal rehabilitation treatment at a chain of ...
Source: Spine - Category: Orthopaedics Tags: EPIDEMIOLOGY Source Type: research
Conclusion. The present case demonstrated the need to extensively investigate causes of generalized bone pain in patients with hypophosphatemia, as TIO is highly curable. Importantly, 68Ga-DOTATATE PET/CT imaging successfully identified the FGF23 producing tumor, which was undetectable by conventional imaging, favoring its early use in suspected TIO presentation. The present report highlights the importance of timely diagnosis of this complex medical condition, aiming to improve general awareness and enable better clinical outcomes for this rare disorder.PMID:34523297 | DOI:10.2478/enr-2021-0017
Source: Endocrine Regulations - Category: Endocrinology Authors: Source Type: research
CONCLUSIONS AND POTENTIAL IMPACT: The findings will help determine whether adding PBMT to a physical therapist-supervised exercise protocol is more effective than the exercise protocol alone for persistent LBP. This study has the potential to guide clinical practice toward innovative ways of providing health care.PMID:34499157 | DOI:10.1093/ptj/pzab201
Source: Physical Therapy - Category: Physiotherapy Authors: Source Type: research
Work. 2021 Aug 27. doi: 10.3233/WOR-213557. Online ahead of print.ABSTRACTBACKGROUND: Many studies have emphasized the importance of stabilization exercises (SE) for the management of non-specific low back pain (NSLBP), yet there is no study assessing all aspects of core stability in comparing SE and other exercises.OBJECTIVE: To investigate the effects of SE on pain and core stability by using core stability tests that focus on all aspects of core stability in patients with NSLBP.METHODS: Thirty-seven individuals with chronic NSLBP were randomly divided into two groups as SE and conventional exercises (CE). Both groups un...
Source: Work - Category: Occupational Health Authors: Source Type: research
Low back pain (LBP) is the leading cause of years lost to disability worldwide 104 with an economic burden comparable to cardiovascular disease, cancer, mental health, and autoimmune diseases 61. Up to 40% of people who experience an episode of acute LBP (defined as pain lasting less than six weeks)24,85 develop chronic pain (pain lasting longer than three months) 22,36, and interventions designed to prevent the development of chronic LBP during have not been effective 8,32,41,77,91.  A critical issue is the lack of robust mechanistic explanations for chronic LBP; in 85 – 95% of LBP cases 26,43,108, a pathoanato...
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research
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