Molecules, Vol. 26, Pages 4563: A Review on Phytochemicals of the Genus Maytenus and Their Bioactive Studies

Molecules, Vol. 26, Pages 4563: A Review on Phytochemicals of the Genus Maytenus and Their Bioactive Studies
Molecules doi: 10.3390/molecules26154563
Authors:
Huang
Chen
Ma
Xu
Jia
Deng
Li
Yuan

The genus Maytenus is a member of the Celastraceae family, of which several species have long been used in traditional medicine. Between 1976 and 2021, nearly 270 new compounds have been isolated and elucidated from the genus Maytenus. Among these, maytansine and its homologues are extremely rare in nature. Owing to its unique skeleton and remarkable bioactivities, maytansine has attracted many synthetic endeavors in order to construct its core structure. In this paper, the current status of the past 45 years of research on Maytenus, with respect to its chemical and biological activities are discussed. The chemical research includes its structural classification into triterpenoids, sesquiterpenes and alkaloids, along with several chemical synthesis methods of maytansine or maytansine fragments. The biological activity research includes activities, such as anti-tumor, anti-bacterial and anti-inflammatory activities, as well as HIV inhibition, which can provide a theoretical basis for the better development and utilization of the Maytenus.

Source: Molecules - July 28, 2021 Category: Chemistry Authors: Huang Chen Ma Xu Jia Deng Li Yuan Tags: Review Source Type: research