Galectin-3 promotes noncanonical inflammasome activation through intracellular binding to lipopolysaccharide glycans [Immunology and Inflammation]

Cytosolic lipopolysaccharides (LPSs) bind directly to caspase-4/5/11 through their lipid A moiety, inducing inflammatory caspase oligomerization and activation, which is identified as the noncanonical inflammasome pathway. Galectins, β-galactoside–binding proteins, bind to various gram-negative bacterial LPS, which display β-galactoside–containing polysaccharide chains. Galectins are mainly present intracellularly, but their interactions with cytosolic...

Source: Proceedings of the National Academy of Sciences - July 23, 2021 Category: Science Authors: Tzu-Han Lo, Hung-Lin Chen, Cheng-I Yao, I-Chun Weng, Chi-Shan Li, Chi-Chun Huang, Nien-Jung Chen, Chun-Hung Lin, Fu-Tong Liu Tags: Immunology and Inflammation Biological Sciences Source Type: research