Evolution of Systemic Therapy in Metastatic Pancreatic Ductal Adenocarcinoma

Pancreatic ductal adenocarcinoma is characterized by early systemic dissemination, a complex tumor microenvironment, as well as significant intratumoral and intertumoral heterogeneity. Treatment options and survival in pancreatic ductal adenocarcinoma have improved steadily over the last 3  decades. Although cytotoxic chemotherapy is currently the mainstay of treatment for pancreatic ductal adenocarcinoma, evolving therapeutic strategies are aimed at targeting the tumor microenvironment, metabolism, and the tumor–host immune balance.
Source: Surgical Oncology Clinics of North America - Category: Surgery Authors: Source Type: research