RNA polymerase spoiled for choice as transcription begins [Biochemistry]

Papers concerning transcription, and its regulation at promoters, abound in the scientific literature, but reports about initiation, defined as the moment that the first 3′−5′phosphodiester bond of a new transcript is forged, are scarce. In PNAS, Skalenko et al. (1), working with the bacterial multisubunit DNA-dependent RNA polymerase (RNAP), combine...

Source: Proceedings of the National Academy of Sciences - July 22, 2021 Category: Science Authors: Stephen J. W. Busby Tags: Biochemistry, Commentaries Commentary Source Type: research