An otopetrin family proton channel promotes cellular acid efflux critical for biomineralization in a marine calcifier [Physiology]

Otopetrins comprise a family of proton-selective channels that are critically important for the mineralization of otoliths and statoconia in vertebrates but whose underlying cellular mechanisms remain largely unknown. Here, we demonstrate that otopetrins are critically involved in the calcification process by providing an exit route for protons liberated by the...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: Physiology Biological Sciences Source Type: research