Methodological Considerations in N-of-1 Trials of Traditional Chinese Medicine

Evid Based Complement Alternat Med. 2021 Jun 23;2021:6634134. doi: 10.1155/2021/6634134. eCollection 2021.ABSTRACTMore and more scholars choose N-of-1 trials for TCM clinical research. However, the quality of the experimental designs was uneven. Accumulating more than eight years of experience in exploring the N-of-1 trials of TCM, the authors and their team searched the related literature in main Chinese and English databases, referenced to relevant Chinese and international guidelines. The design, implementation, and data analysis of N-of-1 trials of TCM are still in in-depth exploration and practice. "Carryover effect" may affect the design and quality of the trials. Individualized treatment should be guided by the classic theories of TCM. It is expected to formulate reasonable observation periods and pairs and closely integrate individual and group statistical analysis.PMID:34257690 | PMC:PMC8245250 | DOI:10.1155/2021/6634134

Source: Evidence-based Complementary and Alternative Medicine - July 14, 2021 Category: Complementary Medicine Authors: Haiyin Huang Jiaqi An Lizhi Lu Mingli Wang Huijia Chen Xinlin Chen Lihua Shen Source Type: research