LRG1 facilitates corneal fibrotic response by inducing neutrophil chemotaxis via Stat3 signaling in alkali-burned mouse corneas

In conclusion, LRG1 promotes the corneal fibrotic response by stimulating neutrophils infiltration via the modulation of the IL-6/Stat3 signaling pathway. Therefore, LRG1 could be targeted as a promising therapeutic strategy for patients with corneal fibrosis.PMID:34260299 | DOI:10.1152/ajpcell.00517.2020

Source: Am J Physiol Cell Ph... - July 14, 2021 Category: Cytology Authors: Bingjie Yu Lingling Yang Shan Song Weina Li Huifeng Wang Jun Cheng Source Type: research