CNIO researchers clarify the role of the two isoforms of KRAS, the most common oncogene in humans

(Centro Nacional de Investigaciones Oncol ó gicas (CNIO)) Even though KRAS4B is the dominant form in cancer, the KRAS4A mutant is also oncogenic, and it is even more active. In the words of the authors, " KRAS4AG12V alone, in the absence of KRAS4B, can induce lung cancer and metastasis in 20 percent of individuals. Our results suggest that for therapies to be effective, the two KRAS isoforms should be targeted. "
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news