Reconfiguration and dedifferentiation of functional networks during cognitive control across the adult lifespan

We report two major findings: (1) Functional connectivity patterns during initiation, inhibition, and shifting were more similar in older ages, particularly for control and default networks, a pattern consistent with dedifferentiation of the neural correlates associated with cognitive control; and (2) Networks exhibited age-related reconfiguration such that frontal, default, and dorsal attention networks were more integrated whereas sub-networks of somato-motor system were more segregated in older age. Together these findings offer new evidence for dedifferentiation and reconfiguration of functional connectivity underlying different aspects of cognitive control in normal aging.PMID:34256190 | DOI:10.1016/j.neurobiolaging.2021.03.019

Source: Neurobiology of Aging - July 13, 2021 Category: Geriatrics Authors: Jenny R Rieck Giulia Baracchini Daniel Nichol Herv é Abdi Cheryl L Grady Source Type: research