IV tPA given in the golden hour for emergent large vessel occlusion stroke improves recanalization rates and clinical outcomes

Early thrombolysis for acute ischemic stroke (AIS) due to emergent large vessel occlusion (ELVO) is associated with better clinical outcome. This is thought to be due to greater tissue salvage with earlier recanalization. We explored whether ultra-early administration of intravenous tissue plasminogen activator (IV tPA) within 60  min (Golden Hour) of symptom onset for AIS due to ELVO is associated with a higher rate of recanalization.

Source: Journal of the Neurological Sciences - July 14, 2021 Category: Neurology Authors: Rodica Di Lorenzo, Maher Saqqur, Andrew Blake Buletko, Lacy Sam Handshoe, Bhageeradh Mulpur, Julian Hardman, Megan Donohue, Dolora Wisco, Ken Uchino, M. Shazam Hussain Source Type: research