WVU researcher leads effort to reduce data-transfer error in radiation therapy
(West Virginia University) As the complexity of radiation therapy has grown, so too has the amount of data that goes into treatment machines. With more data comes more opportunity for errors in data transfer. Ramon Alfredo Siochi--WVU's director of medical physics--is working to make those errors less likely.
In conclusion, the findings of the present study suggested that SIK2 may be involved in CRC carcinogenesis and glycolysis by regulating TRIM28 expression. These findings could provide a novel approach to targeted therapy and clinical diagnosis of CRC in the future.PMID:34558647 | DOI:10.3892/mmr.2021.12460
habason The management of patients with metastatic cancer is rapidly changing. Historically, radiotherapy was utilized for the treatment of localized disease or for palliation. While systemic therapy remains the mainstay of management for patients with metastatic cancer, radiotherapy is becoming increasingly important not only to palliate symptoms, but also to ablate oligometastatic or oligoprogressive disease and improve local control in the primary site. There is emerging evidence in multiple solid malignancies that patients with low volume metastatic disease that undergo local ablative therapy to metastatic sites ma...
Recent randomized studies have suggested improvements in progression-free and overall survival with the addition of stereotactic body radiation therapy (SBRT, also known as stereotactic ablative radiotherapy, SABR) in oligometastatic NSCLC patients. Given the novelty and complexity of incorporating SBRT in the oligometastatic setting, the multidisciplinary American Radium Society (ARS) Lung Cancer Panel was assigned to create Appropriate Use Criteria (AUC) on SBRT as part of consolidative local therapy for oligometastatic and oligoprogressive NSCLC patients.
Conclusions: Thermoplastic mask could significantly reduce positioning errors in the radiotherapy of breast cancer. Although more discomfort was found in the TM group, it could be eliminated as the treatment progresses.PMID:34554027 | DOI:10.1177/15330338211043037
CONCLUSION: Metastatic disease of bone is a common condition that affects many cancer patients. In our institution's series of MDF treated with RT, we only found one patient who sustained a pathologic fracture after RT treatment with an unrecognized impending fracture. As only half of the patients were referred for an orthopedic evaluation prior to RT, continued education of medical and radiation oncologists regarding the signs and symptoms of impending pathologic fracture is warranted.Level of Evidence: IV.PMID:34552408 | PMC:PMC8259171
CONCLUSION: Orocutaneous fistula after oral cavity resection has significant incidence and clinical impact. Risk of OCF persists despite advances in reconstructive options; there is a trend toward higher risk after prior radiation.PMID:34553635 | DOI:10.1177/00034894211047463
Title: Radiation Therapy for Breast Cancer May Have Long-Term Risk for the HeartCategory: Health NewsCreated: 9/22/2021 12:00:00 AMLast Editorial Review: 9/23/2021 12:00:00 AM
The treatment landscape of metastatic castration-resistant prostate cancer (mCRPC) has dramatically improved over the last decade; however, patients with visceral metastases are still faced with poor outcomes. Phosphatase and tensin homolog (PTEN) loss is observed in 40%–60% of mCRPC patients and is also associated with a poor prognosis. Several PI3K/AKT/mTOR pathway inhibitors have been studied, with disappointing anti-tumor activity. Here, we present a case of a patient with heavily treated mCRPC who had a modest tumor response to concurrent carboplatin, abiraterone acetate/prednisone, and liver-directed radiation ...
ConclusionLocal ablative radiation therapy directed to progressive metastasis is a non-invasive, well tolerated treatment with efficacy on prolonging clinical benefit of systemic therapies with ARTT. Patients who underwent RT>6 months from the start of ARTT presented a statistically better OS and PFS compared with patients who underwent radiotherapy
Up to the late nineties, most departments used Cobalt-60 (Co-60) Units for radiation therapy (RT) for superficially located indications, including postmastectomy RT (PMRT) for early breast cancer. With the transition to linear accelerator photon-based RT, bolus material was often added to allow for a similar surface dose distribution as received with the Co-60 machines due to the skin sparing effect of photons . Bolus serves as a tissue equivalent material that shifts the 95-100% isodose towards the skin and subcutaneous tissue (depending on the thickness of bolus and subcutaneous tissue) .