Pomegranate peel extract polyphenols attenuate the SARS-CoV-2 S-glycoprotein binding ability to ACE2 Receptor: In silico and in vitro studies

In this study, both in silico and in vitro methods were employed for evaluation of pomegranate peel extract (PoPEx), their major polyphenols, as well as their major metabolite urolithin A, to attenuate the contact of S-glycoprotein RBD and ACE2. Our results showed that PoPEx, punicalin, punicalagin and urolithin A exerted significant potential to block the S-glycoprotein-ACE2 contact. These in vitro results strongly confirm the in silico predictions and provide a valuable insight in the potential of pomegranate polyphenols for application in SARS-CoV-2 infection.PMID:34246969 | DOI:10.1016/j.bioorg.2021.105145

Source: Bioorganic Chemistry - July 11, 2021 Category: Chemistry Authors: Relja Suru čić Maja Travar Miroslav Petkovi ć Biljana Tubi ć Milo š P Stojiljković Milkica Grabe ž Katarina Šavikin Gordana Zduni ć Ranko Škrbić Source Type: research