Ultrasound guided needle biopsy of axilla to evaluate nodal metastasis after preoperative systemic therapy in cohort of 106 breast cancers enriched with BRCA1/2 pathogenic variant carriers

ConclusionFNAC after PST has low FPR and is useful to predict residual axillary disease and to streamline surgical decision making regarding ALND both inBRCA1/2 positive and negative subgroups. FNR is high in overall cohort and FNAC alone are not able to predict ypCR and omission of further axillary surgery. However, FNAC performance inBRCA1/2 positive subgroup is more promising and further research with larger number of cases is necessary to confirm the results.
Source: Hereditary Cancer in Clinical Practice - Category: Cancer & Oncology Source Type: research