Lyme arthritis: linking infection, inflammation and autoimmunity

Nature Reviews Rheumatology, Published online: 05 July 2021; doi:10.1038/s41584-021-00648-5Lyme arthritis, a manifestation of Lyme disease, can sometimes persist in a chronic post-infectious disease. In this Review, the authors argue that post-infectious Lyme arthritis could act as a model to improve understanding of other forms of chronic arthritis.
Source: Nature Reviews Rheumatology - Category: Rheumatology Authors: Source Type: research

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CONCLUSION. The number of requested B. burgdorferi serological tests was highest in primary care. A clear guideline describing how to diagnose LA is needed in primary and secondary care alike. FUNDING none. TRIAL REGISTRATION Under current Danish law, no formal ethical approval was required for this study. Approval for this study was obtained from the Danish Data Protection Agency (no. 2012-58-0004).PMID:34983732
Source: Danish Medical Journal - Category: General Medicine Authors: Source Type: research
Best Pract Res Clin Rheumatol. 2021 Dec 31:101736. doi: 10.1016/j.berh.2021.101736. Online ahead of print.ABSTRACTRheumatoid arthritis (RA) can have various infectious mimics. As immunosuppressive agents used in treatment can aggravate the underlying infections, correct diagnosis of RA and ruling out infections is important. Numerous viral infections (Parvovirus B19, Hepatitis B, Hepatitis C, Chikungunya and other alphaviruses, human immunodeficiency virus (HIV) and various other viruses), mycobacterial infections (Poncet's disease, tubercular septic arthritis, and leprosy), bacterial arthritis, brucellosis and Lyme diseas...
Source: Cell Research - Category: Cytology Authors: Source Type: research
Am Fam Physician. 2021 Dec 1;104(6):589-597.ABSTRACTSeptic arthritis must be considered and promptly diagnosed in any patient presenting with acute atraumatic joint pain, swelling, and fever. Risk factors for septic arthritis include age older than 80 years, diabetes mellitus, rheumatoid arthritis, recent joint surgery, hip or knee prosthesis, skin infection, and immunosuppressive medication use. A delay in diagnosis and treatment can result in permanent morbidity and mortality. Physical examination findings and serum markers, including erythrocyte sedimentation rate and C-reactive protein, are helpful in the diagnosis but...
Source: American Family Physician - Category: Primary Care Authors: Source Type: research
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