Semaglutide reduces fat accumulation in the tongue: a randomized single-blind, pilot study

Obesity has been linked to the loss of genioglossal muscle and increased fat content in the tongue [1]. Lingual obesogenic sarcopenia accounts for greater collapsibility of the tongue during sleep and frequently leads to obesity related sleep apnea. In particular, fat infiltrates the muscle bundles and affects muscle strength and function, with inverse relationship between muscle lipid content and muscle force, velocity and power [2]. The current therapeutic strategies for obesity related sleep apnea are limited to positive airway pressure devices associated with low patients ’ preference and adherence.
Source: Diabetes Research and Clinical Practice - Category: Endocrinology Authors: Source Type: research