Quantitative genetics: pan-genomes, SVs, and k-mers for GWAS

Trends Genet. 2021 Jun 25:S0168-9525(21)00138-4. doi: 10.1016/j.tig.2021.05.006. Online ahead of print.ABSTRACTFor identification of marker-trait associations (MTAs) for complex traits in animals and plants, thousands of genome-wide association studies (GWAS) were conducted during the past two decades. This involved regular improvement in methodology. Initially, a reference genome and SNPs were used; more recently pan-genomes and the markers structural variations (SVs)/k-mers are also being used.PMID:34183185 | DOI:10.1016/j.tig.2021.05.006

Source: Trends in Genetics : TIG - June 29, 2021 Category: Genetics & Stem Cells Authors: Pushpendra K Gupta Source Type: research