ATF4-dependent heme-oxygenase-1 attenuates diabetic nephropathy by inducing autophagy and inhibiting apoptosis in podocyte

CONCLUSIONS: ATF4 induces autophagy by enhancing the expression of HO-1, and inhibits podocyte apoptosis in DN. Treatment with the HO-1 agonist reduced proteinuria, apoptosis, and enhanced autophagy response, and thus improved renal function in DN mice.PMID:34157937 | DOI:10.1080/0886022X.2021.1936040

Source: Renal Failure - June 23, 2021 Category: Urology & Nephrology Authors: Shizhu Yuan Xudong Liang Wenfang He Mingzhu Liang Juan Jin Qiang He Source Type: research