mPPI: a database extension to visualize structural interactome in a one-to-many manner

AbstractProtein –protein interaction (PPI) databases with structural information are useful to investigate biological functions at both systematic and atomic levels. However, most existing PPI databases only curate binary interactome. From the perspective of the display and function of PPI, as well as the structu ral binding interface, the related database and resources are summarized. We developed a database extension, named mPPI, for PPI structural visualization. Comparing with the existing structural interactomes that curate resolved PPI conformation in pairs, mPPI can visualize target protein and its mul tiple interactors simultaneously, which facilitates multi-target drug discovery and structure prediction of protein macro-complexes. By employing a protein–protein docking algorithm, mPPI largely extends the coverage of structural interactome from experimentally resolved complexes. mPPI is designe d to be a customizable and convenient plugin for PPI databases. It possesses wide potential applications for various PPI databases, and it has been used for a neurodegenerative disease–related PPI database as demonstration. Scripts and implementation guidelines of mPPI are documented at the databa se tool website.Database URL http://bis.zju.edu.cn/mppi/
Source: Database : The Journal of Biological Databases and Curation - Category: Databases & Libraries Source Type: research