Utility of fractional exhaled nitric oxide in interstitial lung disease

The majority of interstitial lung diseases (ILDs) develop rapidly and are associated with a poor prognosis. Therefore, new noninvasive markers are needed to guide the classification and prognostication of ILD. We enrolled 95 patients with ILD, including dermatomyositis-associated ILD ( n = 69), Sj ögren’s syndrome-associated ILD ( n = 7), mixed connective tissue disease-associated ILD ( n = 9), idiopathic pulmonary fibrosis ( n = 5) and hypersensitivity pneumonitis ( n = 5), 82 patients with connective tissue disease but without ILD as well as 24 healthy controls, then evaluated fractional exhaled nitric oxide (FeNO50; 50 ml s –1 ) (Bisenkov et al 2006 Vestn. Khir. Im. I. I. Grek. 165 9 –14), pulmonary function and high-resolution computed tomography (HRCT) scores. Blood samples were analyzed and bronchoalveolar lavage fluid parameters were measured. There was no significant difference in FeNO50 values between different s...
Source: Journal of Breath Research - Category: Respiratory Medicine Authors: Source Type: research