Psychiatric disorders of the combination of levetiracetam either with lacosamide or perampanel: a retrospective cohort study

Conclusion As the frequency of psychiatric disorders was higher with levetiracetam  + perampanel therapy, levetiracetam + lacosamide may be preferable. These disorders tended to develop within 1 month of therapy and were not dose-dependent. Antiepileptic drugs should be cautiously prescribed to avoid psychiatric disorders.
Source: International Journal of Clinical Pharmacy - Category: Drugs & Pharmacology Source Type: research