A rare case of antibody against enhancement media interfering with crossmatching: A case report and review of literature

S Anuragaa, Dibyajyoti Sahoo, B Abhishekh, Revathy NairAsian Journal of Transfusion Science 2021 15(1):100-103Detection of clinically significant alloantibodies during pretransfusion testing is essential before any blood transfusion. Sometimes, clinically insignificant antibodies unrelated to blood group antigen may interfere with routine testing. Their interpretation is often made only after tedious immunohematology workup resulting in the exclusion of all possible clinically significant antibodies. We encountered such incidence which interfered with crossmatching. In our case, direct antiglobulin test was negative, indirect antiglobulin test and autocontrol were positive with pan-reactive antibody screening test, and group-specific units were incompatible. After meticulous workup, we could find that these antibodies were directed against the enhancement media, low-ionic strength solution in this case.
Source: Asian Journal of Transfusion Science - Category: Hematology Authors: Source Type: research