HIF-1{alpha} is a negative regulator of interferon regulatory factors: Implications for interferon production by hypoxic monocytes [Immunology and Inflammation]

Patients with severe COVID-19 infection exhibit a low level of oxygen in affected tissue and blood. To understand the pathophysiology of COVID-19 infection, it is therefore necessary to understand cell function during hypoxia. We investigated aspects of human monocyte activation under hypoxic conditions. HMGB1 is an alarmin released by stressed...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: Immunology and Inflammation, Coronavirus (COVID-19) Biological Sciences Source Type: research