The only conserved microsatellite in coding regions of ebolavirus is the editing site

Biochem Biophys Res Commun. 2021 Jun 4;565:79-84. doi: 10.1016/j.bbrc.2021.05.093. Online ahead of print.ABSTRACTLots of viral genomes were found to contain microsatellites (SSRs) including Ebolavirus, and majority of Ebolavirus microsatellite sites are distributed in protein-coding regions of the genomes. Here, we totally identified 212 reserved microsatellite sites in the protein-coding regions of 213 genomic sequences from five Ebolavirus species. In these reserved microsatellite sites, there is only one significantly conserved microsatellite site among the sample Ebolavirus genomic sequences, and this microsatellite is located at RNA editing site of the GP gene, indicating the selective relevance with RNA editing there. This analysis may help to further explore the biological significance of various microsatellites in Ebolavirus genomes.PMID:34098315 | DOI:10.1016/j.bbrc.2021.05.093

Source: Biochemical and Biophysical Research communications - June 7, 2021 Category: Biochemistry Authors: Douyue Li Ruixue Shi Hongxi Zhang Hanrou Huang Saichao Pan Yuling Liang Shan Peng Zhongyang Tan Source Type: research