Antiepileptic drugs and serotonin syndrome- A systematic review of case series and case reports

Serotonin syndrome (SS) is an iatrogenic drug ‑induced clinical syndrome characterized by a combination of altered mental activity, neuromuscular abnormalities, and autonomic disturbances. Serotonin syndrome typically results from the increased intrasynaptic concentration of serotonin or 5-hydroxytryptamine (5-HT). There are seven types of 5- HT receptors (5-HT1 to 5-HT7), each with several subtypes. The 5-HT2A and 5-HT1A are the two main receptors implicated in the pathophysiology of SS [1].

Source: Seizure: European Journal of Epilepsy - June 6, 2021 Category: Neurology Authors: Sanjay Prakash, Chaturbhuj Rathore, Kaushik Rana, Harsh Patel Source Type: research