Ten-year treatment complication outcomes of radical prostatectomy vs external beam radiation vs brachytherapy for 1503 patients with intermediate risk prostate cancer

To compare 10-year late complications of radical prostatectomy (RP) versus external-beam-radiation-therapy (EBRT) versus brachytherapy (BT).
Source: Brachytherapy - Category: Cancer & Oncology Authors: Source Type: research

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CONCLUSION: A nomogram tuned to the detection of non-localized disease on PSMA/PET in HR-PCa patients is significantly prognostic of important clinical endpoints, with performance comparable to STAR-CAP and superior to other tools. These data strongly suggest that upstaging based on PSMA PET/CT provides clinically relevant information and warrant prospective validation.PMID:34700573 | DOI:10.1016/j.ijrobp.2021.07.135
Source: Ann Oncol - Category: Cancer & Oncology Authors: Source Type: research
ConclusionThe two approaches used in this study showed similar patterns of alterations regarding general and disease specific HRQL with mild superiority for IMRT for the first 6 months after radiation therapy. Comparison of results between the 3DCRT and the IMRT groups revealed no substantial degrees of impairment in rectal toxicity and sexual function despite the dose escalation in the IMRT protocol. Thus, IMRT seems to offer a good treatment delivery approach with favorable HRQL outcomes.
Source: QJM - Category: Internal Medicine Source Type: research
Multiple management options are available for clinically localized prostate cancer, including definitive external beam radiation therapy (EBRT), radical prostatectomy (RP), brachytherapy (BT), and, for patients with low-risk and favorable intermediate-risk disease, active surveillance.1 Given the high cure rate and long life expectancy after treatment, quality of life (QOL) often remains the paramount factor in decision-making for patients with clinically localized disease.2 Several validated patient-reported outcome (PRO) instruments exist for prostate cancer.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Editorial Source Type: research
Conclusions: 18F-DCFPyL detected more lesions than mpMRI within the same FOV across all therapy groups with the most lesions in those who had undergone both prostatectomy and radiation (89 lesions). MRI detected more lesions than 18F-DCFPyL in the prostate bed, primarily in the surgical and radiotherapy groups (35 and 36 lesions, respectively) with the least number of lesions seen in the dual therapy group (24 lesions). Concordance rates between the two modalities was comparably modest among the treatment groups (20.8% for surgery, 33.3% for radiation and 21.2% for both.) Curative therapy method (surgery, radiation or both...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Prostate/GU Source Type: research
Purpose: Men with Gleason grade group 5 (GG5) prostate cancer (PCa) have particularly aggressive disease, and current guidelines recommend external beam radiation therapy (EBRT) with or without a brachytherapy (BT) boost plus androgen deprivation therapy (ADT) or radical prostatectomy (RP) with pelvic lymph node dissection. The largest retrospective cohort study to date previously demonstrated that EBRT plus a BT boost was associated with significantly better prostate-cancer specific mortality (PCSM) and lower rate of distant metastases (DM) compared with EBRT alone (Kishan, JAMA 2018).
Source: Brachytherapy - Category: Cancer & Oncology Authors: Source Type: research
Conclusion[18F]PSMA-1007-PET/CT showed a high positivity rate in patients with biochemically recurrent PCa. PSA value and PSA velocity were significant predictors of scan positivity as well as of the presence and number of bone and soft tissue lesions and the number of LN lesions. Our findings can guide clinicians in optimal patient selection for [18F]PSMA-1007-PET/CT and support further research leading to the development of a prediction nomogram.
Source: EJNMMI Research - Category: Radiology Source Type: research
CONCLUSIONS: In men with recurrent prostate cancer after radiotherapy, biopsy findings and MRI can be used to select index lesions potentially amenable for sPGA and can guide patient evaluation for inclusion in clinical trials of sPGA following radiation failure. Larger, prospective studies are required to evaluate both the role of MRI and clinical criteria in guiding focal salvage therapy and the effectiveness of this modality for radiorecurrent prostate cancer.PMID:33583697 | DOI:10.1016/j.urolonc.2021.01.011
Source: Urologic Oncology - Category: Urology & Nephrology Authors: Source Type: research
CONCLUSIONS: In men with recurrent prostate cancer after radiotherapy, biopsy findings and MRI can be used to select index lesions potentially amenable for sPGA and can guide patient evaluation for inclusion in clinical trials of sPGA following radiation failure. Larger, prospective studies are required to evaluate both the role of MRI and clinical criteria in guiding focal salvage therapy and the effectiveness of this modality for radiorecurrent prostate cancer. PMID: 33583697 [PubMed - as supplied by publisher]
Source: Urologic Oncology - Category: Urology & Nephrology Authors: Tags: Urol Oncol Source Type: research
CONCLUSION: Prostate cancer treatment choices differ substantially between men diagnosed in private and public health services in Victoria. These differences are not explained by disease severity or comorbidity. PMID: 32996611 [PubMed - as supplied by publisher]
Source: Medical Journal of Australia - Category: General Medicine Tags: Med J Aust Source Type: research
CONCLUSION: PDR salvage brachytherapy in local recurrent previously irradiated prostate cancer is efficient with low late toxicity. Salvage-brachytherapy represents a valuable therapeutic option for the treatment of previously irradiated locally recurrent prostate cancer. PMID: 32593646 [PubMed - as supplied by publisher]
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - Category: Radiology Authors: Tags: Radiother Oncol Source Type: research
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