Catheter-based biopsy leading to early surgical intervention of the pulmonary artery intimal sarcoma

Publication date: Available online 30 May 2021Source: Journal of Cardiology CasesAuthor(s): Hideo Takahashi, Takayuki Onishi, Tomo Ando, Tetsuya Tobaru
Source: Journal of Cardiology Cases - Category: Cardiology Source Type: research

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Clear cell sarcoma (CCS) is a deadly malignancy affecting adolescents and young adults. It is characterized by reciprocal translocations resulting in expression of the chimeric EWSR1-ATF1 or EWSR1-CREB1 fusion proteins, driving sarcomagenesis. Besides these characteristics, CCS has remained genomically uncharacterized. Copy number analysis of human CCSs showed frequent amplifications of the MITF locus and chromosomes 7 and 8. Few alterations were shared with Ewing sarcoma or desmoplastic, small round cell tumors, which are other EWSR1-rearranged tumors. Exome sequencing in mouse tumors generated by expression of EWSR1-ATF1...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
We present the case of a previously healthy 36-year-old male, who was admitted to hospital with new-onset painful obstructive jaundice and final diagnosis of isolated MS was made after through investigations. We are pleased to report that he had favorable response to the treatment and remains well.Case Rep Gastroenterol 2021;15:695 –702
Source: Case Reports in Gastroenterology - Category: Gastroenterology Source Type: research
In this study, data from a Dutch nationwide database are used to (1) assess whether perioperative management of STS follows ESMO guidelines, (2) characterize prognostic factors for overall survival (OS), and (3) assess the association between perioperative treatment and survival.METHODS: All intermediate- or high-grade, localized STS cases, who have undergone surgery and diagnosed between 2000 and 2017, were identified in the Netherlands Cancer Registry (NCR) database. Variables with demographic, treatment, and survival data were obtained. Survival curves were estimated by Kaplan-Meier's method, and the effect of prognosti...
Source: Sarcoma - Category: Cancer & Oncology Authors: Source Type: research
This study indicated that the shrinkage of tail-like lesions did not have a significant effect on complete resection or improvements of clinical outcomes. A more comprehensive evaluation is needed to elaborate on the surgical strategy.
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
ConclusionsThe Capanna technique is a reliable alternative method for revision reconstruction of a segmental bone defect caused by a previous failed surgical procedure.Level of EvidenceLevel IV, therapeutic study.
Source: Annals of Surgical Oncology - Category: Cancer & Oncology Source Type: research
Left heart sarcomas and very complex left heart tumors may require cardiac explantation, ex vivo resection and reconstruction and re implantation of the heart - cardiac autotransplantation. Combined extensive cardiac resection and pneumonectomy may require a two-step approach - the Texas Two Step. Finally, extensive ventricular tumors may require complete cardiac replacement. Our techniques for these difficult cases are discussed in this manuscript.
Source: Operative Techniques in Cardiac and Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Source Type: research
We report an advanced cardiac intimal sarcoma in the right atrium of a 19-year-old man that was complicated by tumor-related IVC thrombosis. We initially performed partial tumor resection and vena cava thrombectomy to resolve the circulatory obstruction, because complete resection was difficult due to the invading malignancy and an unclear margin. The patient received adjuvant chemo- and radiotherapy along with anticoagulant therapy. After 3 months, the border of the residual sarcoma was clear, and the patient underwent a secondary complete sarcoma excision (including that of the right atrium) and a suprahepatic vena cava ...
Source: Journal of Cardiac Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: CASE REPORT Source Type: research
Paulo Rodrigues-Santos Soft Tissue Sarcomas (STS) are a heterogeneous and rare group of tumors. Immune cells, soluble factors, and immune checkpoints are key elements of the complex tumor microenvironment. Monitoring these elements could be used to predict the outcome of the disease, the response to therapy, and lead to the development of new immunotherapeutic approaches. Tumor-infiltrating B cells, Natural Killer (NK) cells, tumor-associated neutrophils (TANs), and dendritic cells (DCs) were associated with a better outcome. On the contrary, tumor-associated macrophages (TAMs) were correlated with a poor outcome. The ...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
This study aims to explain the pathophysiology and contribute to a P4 medicine model for use by cardiologists, pathologists, and oncologists. We created six gene/protein heart-related and tumor-related targets high-confidence interactomes, which unfold the main pathways that may lead to cardiac diseases (heart failure, hypertension, coronary artery disease, arrhythmias), i.e., the sympathetic nervous system, the renin-angiotensin-aldosterone axis and the endothelin pathway, and excludes others, such as the K oxidase or cytochrome P450 pathways. We concluded that heart cancer patients could be affected by beta-adrenergic bl...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
We present a case of histiocytic sarcoma with multisystem involvement, including an obstructing pancreatic head mass. F18-FDG PET/CT is a valuable tool in staging and assessment of response to therapy in this rare entity. Knowing the diverse metastatic pattern of HS will help avoid imaging pitfalls for the diagnosis after pathologic diagnosis is made.PMID:34330800 | DOI:10.2967/jnmt.121.262247
Source: Journal of Nuclear Medicine Technology - Category: Nuclear Medicine Authors: Source Type: research
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