COVID-19-Associated Acute Respiratory Distress Syndrome: Lessons from Tissues and Cells

Reports examining lung histopathology in COVID-19 infection provide an essential body of information for clinicians and investigators. SARS-CoV-2-induced lung injury is complex, involving the airways, alveoli, and pulmonary vessels. Although no anatomic marker is specific the signature histologic lesion is diffuse alveolar damage (DAD). The biologic and molecular mechanisms that drive this pattern of injury are unknown, and the relationship of SARS-CoV-2-induced DAD to physiologic alterations and clinical outcomes in COVID-19-associated acute respiratory distress syndrome is undefined. Additional histologic patterns that may be variant phenotypes have been reported. These are key issues for future clinical and experimental research.
Source: Critical Care Clinics - Category: Intensive Care Authors: Source Type: research