Routine first-trimester combined screening for pre-eclampsia: pregnancy-associated plasma protein-A or placental growth factor?

CONCLUSION: Using PlGF or PAPP-A in routine first trimester combined screening with maternal characteristics, blood pressure and uterine artery Doppler does not make an appreciable clinical difference to the detection of PE or SGA. Depending on the setting, biomarkers should be chosen to achieve a good compromise between performance and measurement requirements. This pragmatic effectiveness study suggests that combined screening for PE can be successfully implemented in public healthcare settings without changing current protocols for the assessment of PAPP-A in the first trimester. This article is protected by copyright. All rights reserved.PMID:33998078 | DOI:10.1002/uog.23669
Source: The Ultrasound Review of Obstetrics and Gynecology - Category: Radiology Authors: Source Type: research