Four new xanthones and their cytotoxicity from the stems of Garcinia schomburgkiana

AbstractFour new xanthones, named schomburgones C-F (1 ‒4), along with six known xanthones (5 ‒10) were isolated from the stems ofGarcinia schomburgkiana. Their structures were determined by spectroscopic analysis especially 1D and 2D NMR spectroscopies. The isolated compounds were evaluated for their cytotoxicity against five human cancer cell lines. Furanoxanthones4 ‒6 showed potent cytotoxicity against four cell lines (KB, HeLa S3, MCF-7 and Hep G2) with IC50 values in the range of 0.18 ‒9.95 µM.Graphic abstract
Source: Journal of Natural Medicines - Category: Drugs & Pharmacology Source Type: research