Podogigants A and B, two new potentiators of amphotericin B activity, from Sordariomycete Podostroma giganteum

AbstractTwo new compounds, podogigants A (1) and B (2), were isolated from the culture broth ofPodostroma giganteum. This is the first report on the identification of secondary metabolites inP. giganteum. The structures of1 and2 were elucidated through spectroscopic analysis, including 2D NMR spectroscopy assisted by chemical derivatization, which revealed the presence of farnesyl- and geranyl-hydroquinone structures, respectively. Compounds1 and2 exhibited no antifungal activity even at a concentration of 64  μg/mL, whereas they potentiated amphotericin B (AmB) activity against several species of fungi. In particular,1 potentiated AmB activity againstC. albicans andR. oryzae by up to 32-fold (MIC value of AmB decreased from 1.0 to 0.032  µg/mL), while2 potentiated AmB activity againstC. albicans by up to 16-fold.
Source: Journal of Natural Medicines - Category: Drugs & Pharmacology Source Type: research