Dermatological and Genital Manifestations of Lyme Disease Including Morgellons Disease

We describe a 49-year-old woman with erosive genital ulcerations, secondary EM rashes and jagged skin lesions associated with Lyme disease. The skin rashes exhibited fibers characteristic of Morgellons disease. Molecular testing confirmed the presence of Borrelia DNA in both vaginal culture and serum specimens. In further studies on a secondary EM lesion containing filaments, Gömöri trichrome staining revealed the presence of collagen in the filaments, while Dieterle and anti-Borrelia immunostaining revealed intracellular and extracellular Borrelia organisms. Intracellular staining for Borrelia was also observed in lymphocytic infiltrates. Lyme disease may present with a variety of genital lesions and dermatological manifestations including Morgellons disease. Careful evaluation is required to determine the presence of Borrelia organisms associated with these dermopathies.PMID:33986606 | PMC:PMC8110212 | DOI:10.2147/CCID.S299526
Source: Clinical, Cosmetic and Investigational Dermatology - Category: Dermatology Authors: Source Type: research

Related Links:

Teaching point: Meticulous anamnesis and a high index of suspicion is needed for the diagnosis of Lyme arthritis. Published on 2021-09-21 11:30:32
Source: Journal of the Belgian Society of Radiology - Category: Radiology Source Type: research
We describe an autochthonous case of Rickettsia slovaca infection in a man 35 years of age from Russia who had tickborne lymphadenopathy. We used ELISA and quantitative PCR testing to further identify DNA and confirm diagnosis. Physicians in Russia should consider similar diseases in differential diagnoses after tick bites.PMID:34546169 | DOI:10.3201/eid2710.204621
Source: Emerging Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research
Emerg Infect Dis. 2021 Oct;27(10):2715-2717. doi: 10.3201/eid2710.210903.ABSTRACTSurveys indicate US residents spent more time outdoors in 2020 than in 2019, but fewer tick bite-related emergency department visits and Lyme disease laboratory tests were reported. Despite ongoing exposure, Lyme disease case reporting for 2020 might be artificially reduced due to coronavirus disease-associated changes in healthcare-seeking behavior.PMID:34545801 | DOI:10.3201/eid2710.210903
Source: Emerging Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research
Rhipicephalus microplus, a vector that can transmit many pathogens to humans and domestic animals, is widely distributed in Yunnan province, China. However, few reports on the prevalence of tick-borne pathogens (TBPs) in Rh. microplus in Yunnan are available. The aim of this study was to detect TBPs in Rh. microplus in Yunnan and to analyze the phylogenetic characterization of TBPs detected in these ticks. The adult Rh. microplus (n = 516) feeding on cattle were collected. The pooled DNA samples of these ticks were evaluated using metagenomic next-generation sequencing (mNGS) and then TBPs in individual ticks were identifi...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Anesth Pain Med. 2021 Jun 26;11(3):e113629. doi: 10.5812/aapm.113629. eCollection 2021 Jun.ABSTRACTThis is a comprehensive literature review of chronic fatigue syndrome (CFS). We provide a description of the background, etiology, pathogenesis, diagnosis, and management regarding CFS. CFS is a multifaceted illness that has many symptoms and a wide array of clinical presentations. As of recent, CFS has been merged with myalgic encephalomyelitis (ME). Much of the difficulty in its management has stemmed from a lack of a concrete understanding of its etiology and pathogenesis. There is a potential association between dysfuncti...
Source: Pain Physician - Category: Anesthesiology Authors: Source Type: research
This article reviews the most common tick-borne infections in the US, including epidemiology, clinical presentation, diagnosis, treatment, and prevention. [Pediatr Ann. 2021;50(9):e350-e355.].PMID:34542342 | DOI:10.3928/19382359-20210825-01
Source: Pediatric Annals - Category: Pediatrics Authors: Source Type: research
owotny Cavalleri The emergence of West Nile virus (WNV) and Usutu virus (USUV) in addition to the autochthonous tick-borne encephalitis virus (TBEV) in Europe causes rising concern for public and animal health. The first equine case of West Nile neuroinvasive disease in Austria was diagnosed in 2016. As a consequence, a cross-sectional seroprevalence study was conducted in 2017, including 348 equids from eastern Austria. Serum samples reactive by ELISA for either flavivirus immunoglobulin G or M were further analyzed with the plaque reduction neutralization test (PRNT-80) to identify the specific etiologic agent. Ne...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
In this study, 22 dogs naturally infected with Babesia canis and 12 healthy dogs were included. Untargeted metabolomics approach identified 601 features with a differential abundance between the healthy group and groups of dogs with babesiosis and different level of kidney function, with 27 of them identified as a match to known standards; while targeted approach identified 17 metabolites with significantly different concentrations between the groups. A pattern of significantly altered metabolites referring to the inflammatory host response, oxidative stress, and energy metabolism modulation in babesiosis was presented. Ou...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
In this study, we cloned, expressed, and purified B. microti PYK I (BmPYKI). Western blotting illustrated that anti-rBmPYKI antibody could specifically recognize the native BmPYKI protein in the lysate of B. microti with a 54-kDa band, which is consistent with the predicted size. In addition, the enzymatic activity of the purified recombinant PYKI (rPYKI) was tested under a range of pH values. The results showed that the maximum catalytic activity could be achieved at pH 7.0. The saturation curves for substrates demonstrated that the Km value for PEP was 0.655 ± 0.117 mM and that for ADP was 0.388 ± 0.087 mM....
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
We describe a 49-year-old woman with erosive genital ulcerations, secondary EM rashes and jagged skin lesions associated with Lyme disease. The skin rashes exhibited fibers characteristic of Morgellons disease. Molecular testing confirmed the presence of Borrelia DNA in both vaginal culture and serum specimens. In further studies on a secondary EM lesion containing filaments, Gömöri trichrome staining revealed the presence of collagen in the filaments, while Dieterle and anti-Borrelia immunostaining revealed intracellular and extracellular Borrelia organisms. Intracellular staining for Borrelia was also observed ...
Source: Clinical, Cosmetic and Investigational Dermatology - Category: Dermatology Authors: Source Type: research
More News: Borrelia | Dermatology | Lyme Disease | Morgellons Disease | Nutrition | Skin | Study | Tickborne Diseases