Combining perampanel and ketamine in super refractory post-traumatic status epilepticus: a case report

Status Epilepticus (SE) is a condition resulting either from the failure of seizure termination mechanisms or from the abnormal activation of prolonged seizure mechanisms. It represents a life-threatening medical emergency associated with high morbidity and mortality that requires prompt diagnosis and treatment. SE treatment begins with a quick-acting benzodiazepine, followed by intravenous (IV) loading and a continuous infusion of antiseizure medications (ASMs). The failure of first- and second-line treatments is defined as “refractory SE” (RSE) and requires infusion of IV anaesthetics.

Source: Seizure: European Journal of Epilepsy - May 8, 2021 Category: Neurology Authors: Paolo Manganotti, Marta Cheli, Alessandro Dinoto, Francesco Biaduzzini, Marinella Tomaselli, Giulia Mazzon, Erik Roman-Pognuz, Stefano Meletti Source Type: research