Dimeric clerodane diterpenoids and antiviral constituents of Dodonaea viscosa

Bioorg Chem. 2021 Apr 15;112:104916. doi: 10.1016/j.bioorg.2021.104916. Online ahead of print.ABSTRACTThree unprecedented dimeric clerodane diterpenoids, dodovisdimers A-C (1-3), along with six known clerodane monomers (4-9), were isolated from Dodonaea viscosa. Compounds 1-3 may be biosynthetically formed via an intermolecular Diels-Alder [4+2] cycloaddition between the coexisting monomers 4-7. The structures of these clerodanes were characterized by spectroscopic techniques, X-ray crystallographic study, and ECD calculations. Some isolates exerted antiviral effects on human influenza A virus (H3N2) in vitro.PMID:33957537 | DOI:10.1016/j.bioorg.2021.104916

Source: Bioorganic Chemistry - May 6, 2021 Category: Chemistry Authors: Xiao-Tong Zhao Chun Lei Jin-Qiu You Ting Zhao Mei-Hua Yu Xun-Long Shi Xiao Hu Ai-Jun Hou Source Type: research