Incidence of gynaecomastia in Klinefelter syndrome adolescents and outcome of testosterone treatment

Conclusion: The incidence of gynaecomastia in KS boys (overall 35.6%) is not increased over typically developing boys. Commencing testosterone when gynaecomastia develops with physiological dose escalation and full adherence can result in the resolution of the gynaecomastia.What is Known:• Gynaecomastia is a common feature in Klinefelter syndrome men.• Hypogonadism occurs from mid-puberty onwards with the absence of the usual rise in testosterone levels.What is New:• The incidence of pubertal gynaecomastia in Klinefelter syndrome is not different from typically developing boys.• Early and prompt starting of testosterone gel treatment and increasing the dose physiologically may help to resolve the gynaecomastia without the need for surgery.
Source: European Journal of Pediatrics - Category: Pediatrics Source Type: research