Diversity of cystic fibrosis chronic rhinosinusitis microbiota correlates with different pathogen dominance

Chronic rhinosinusitis (CRS) reaches a strikingly high prevalence among CF adults (>99%) [1]. While there are several proposed causes of CF-associated CRS (CF-CRS), including abnormal sinus anatomy and aberrant immune responses [2], bacterial infection remains widely implicated [3,4]. The “unified airway” model, whereby microbiota adapt to the upper airways prior to migration to the lungs has become a major impetus for studying CF-CRS microbiology [5,6].
Source: Journal of Cystic Fibrosis - Category: Respiratory Medicine Authors: Tags: Short Communication Source Type: research